Endocrine Abstracts

Islet autoantibodies are strong predictors of type 1 diabetes (T1D), as positivity for multiple, i.e.is two or more, autoantibodies is associated with a risk of around 70% of progression to clinical disease over the next 10 years. Autoantibodies do not, however, predict when T1D will present clinically. We have assessed the utility of signs of dysglycemia for the prediction of the time of disease manifestation and observed that an increase in HbA1c of 10% over 3–12 months...